© 2023 NATON

Publications

Particularly important publications are highlighted (in bold).

  1. Ackermann M, Jonigk DD. Microvascular placental alterations in maternal COVID-19. Am J Obstet Gynecol. 2022;226(1):135–6. doi:10.1016/j.ajog.2021.06.098.
  2. Ackermann M, Tafforeau P, Wagner WL, Walsh CL, Werlein C, Kühnel MP, et al. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med. 2022;205(1):121–5. doi:10.1164/rccm.202103-0594IM.
  3. Ameratunga R, Woon S-T, Sheppard MN, Garland J, Ondruschka B, Wong CX, et al. First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction. J Clin Immunol. 2022;42(3):441–7. doi:10.1007/s10875-021-01187-0.
  4. Aschman T, Mothes R, Heppner FL, Radbruch H. What SARS-CoV-2 does to our brains. Immunity. 2022;55(7):1159–72. doi:10.1016/j.immuni.2022.06.013.
  5. Brandner JM, Boor P, Borcherding L, Edler C, Gerber S, Heinemann A, et al. Contamination of personal protective equipment during COVID-19 autopsies. Virchows Arch. 2022;480(3):519–28. doi:10.1007/s00428-021-03263-7.
  6. Bräuninger H, Stoffers B, Fitzek ADE, Meißner K, Aleshcheva G, Schweizer M, et al. Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart. Cardiovasc Res. 2022;118(2):542–55. doi:10.1093/cvr/cvab322.
  7. Casagrande M, Fitzek A, Spitzer M, Püschel K, Glatzel M, Krasemann S, et al. Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19. Br J Ophthalmol. 2022;106(9):1313–7. doi:10.1136/bjophthalmol-2020-318618.
  8. Gagiannis D, Hackenbroch C, Czech A, Lindner A, Maag N, Bloch W, et al. Clinical, imaging, serological, and histopathological features of pulmonary post-acute sequelae after mild COVID-19 (PASC). medRxiv. 2022:2022.11.29.22282913. doi:10.1101/2022.11.29.22282913.
  9. Gagiannis D, Umathum VG, Bloch W, Rother C, Stahl M, Witte HM, et al. Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2. Am J Clin Pathol. 2022;157(1):54–63. doi:10.1093/ajcp/aqab087.
  10. Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, et al. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. 2022;185(3):493-512.e25. doi:10.1016/j.cell.2021.12.040.
  11. Heinrich F, Roedl K, Jarczak D, Goebels H-L, Heinemann A, Schäfer U, et al. New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19—A Large Postmortem and Clinical Analysis. 2022;14(4):811. doi:10.3390/v14040811.
  12. Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, et al. Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant. Int J Legal Med. 2022;136(1):193–202. doi:10.1007/s00414-021-02618-8.
  13. Heinrich F, Schröder AS, Gerberding A-L, Gerling M, Langenwalder F, Lange P, et al. Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths. Infect. Dis. 2022;28(1):244–7. doi:10.3201/eid2801.211749.
  14. Hirschbühl K, Schaller T, Märkl B, Claus R, Sipos E, Rentschler L, et al. High viral loads: what drives fatal cases of COVID-19 in vaccinees? - an autopsy study. Mod Pathol. 2022;35(8):1013–21. doi:10.1038/s41379-022-01069-9.
  15. Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, Beer M de, et al. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell. 2022;29(2):217-231.e8. doi:10.1016/j.stem.2021.12.010.
  16. Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, et al. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Arch. 2022;481(2):139–59. doi:10.1007/s00428-022-03319-2.
  17. Kamp JC, Neubert L, Ackermann M, Stark H, Werlein C, Fuge J, et al. Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19. IJMS. 2022;23(3):1583. doi:10.3390/ijms23031583.
  18. Krasemann S, Dittmayer C, v. Stillfried S, Meinhardt J, Heinrich F, Hartmann K, et al. Assessing and improving the validity of COVID-19 autopsy studies - a multicenter approach to establish essential standards for immunohistochemical and ultrastructural analyses; 2022.
  19. Neidhardt M, Gerlach S, Mieling R, Laves M-H, Weib T, Gromniak M, et al. Robotic Tissue Sampling for Safe Post-Mortem Biopsy in Infectious Corpses. IEEE Trans. Med. Robot. Bionics. 2022;4(1):94–105. doi:10.1109/TMRB.2022.3146440.
  20. Paparoupa M, Schröder AS, Braunsteiner J, Addo MM, Lütgehetmann M, Roedl K, et al. The effects of SARS-CoV-2 virus type and of vaccination status on causes of death over the course of the COVID-19 pandemic. Deutsches Ärzteblatt international 2022. doi:10.3238/arztebl.m2022.0255.
  21. Pomara C, Salerno M, Miani A, Piscitelli P. Autopsies in COVID-related deaths: The need for following the model of German COVID-19 autopsy registry. Lancet Reg Health Eur. 2022;17:100392. doi:10.1016/j.lanepe.2022.100392.
  22. Stillfried S von, Bülow RD, Röhrig R, Boor P, Böcker J, Schmidt J, et al. First report from the German COVID-19 autopsy registry. The Lancet Regional Health - Europe. 2022;15:100330. doi:10.1016/j.lanepe.2022.100330.
  23. Stillfried S von, Bülow RD, Röhrig R, Meybohm P, Boor P, Böcker J, et al. Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report. Crit Care 2022. doi:10.1186/s13054-022-03945-x.
  24. Stillfried S von, Freeborn B, Windeck S, Boor P. Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin. Pathologie (Heidelb). 2022:1–5. doi:10.1007/s00292-022-01117-w.
  25. Voigtlaender M, Edler C, Gerling M, Schädler J, Ondruschka B, Schröder AS, et al. Thromboembolic events in deceased patients with proven SARS-CoV-2 infection: Frequency, characteristics and risk factors. Thrombosis Research. 2022;218:171–6. doi:10.1016/j.thromres.2022.08.021.
  26. Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, et al. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab. 2022;4(3):310–9. doi:10.1038/s42255-022-00552-6.
  27. Zickler M, Stanelle-Bertram S, Ehret S, Heinrich F, Lange P, Schaumburg B, et al. Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans. Cell Metabolism. 2022;34(1):1–2. doi:10.1016/j.cmet.2021.12.002.
  1. Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell. 2021 Dec 28:S0092-8674(21)01562-2. doi: 10.1016/j.cell.2021.12.040-x.
  2. Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk LE, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grünberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles VG, Floege J, Huber TB; COVID Moonshot consortium, van Rij RP, Costa IG, Schneider RK, Smeets B, Kramann R. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell. 2021 Dec 25:S1934-5909(21)00520-8. doi: 10.1016/j.stem.2021.12.010.
  3. Hirschbühl K, Schaller T, Märkl B, Claus R, Sipos E, Rentschler L, Grosser B, Maccagno A, Kling E, Neidig M, Kröncke T, Spring O, Braun G, Bösmüller H, Seidl M, Esposito I, Pablik J, Hilsenbeck J, Boor P, Beer M, Dintner S, Wylezich C. High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study. ModPath. 2021; preprint, under review.
  4. Walsh CL, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography. Nat Methods. 2021 Dec;18(12):1532-1541. doi: 10.1038/s41592-021-01317-x.
  5. Reichardt M, Moller Jensen P, Andersen Dahl V, Bjorholm Dahl A, Ackermann M, Shah H, Länger F, Werlein C, Kuehnel MP, Jonigk D, Salditt T. 3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography. Elife. 2021 Dec 21;10:e71359. doi: 10.7554/eLife.71359.
  6. van Rüth V, König HH, Bertram F, Schmiedel P, Ondruschka B, Püschel K, Heinrich F, Hajek A. Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic. Public Health. 2021 May;194:60-66. doi: 10.1016/j.puhe.2021.02.026.
  7. Edler C, Klein A, Schröder AS, Sperhake JP, Ondruschka B. Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®). Leg Med (Tokyo). 2021 Jul;51:101895. doi: 10.1016/j.legalmed.2021.101895.
  8. Püschel K, Goebels H, Ondruschka B, Heinrich F, Bräuninger D, Lindner D , Westermann D. Kardiopathologische Befunde bei COVID-19-Sterbefällen. Herzmedizin. 2021 Heft 01, ISSN 0171-9238.
  9. Verhoff M, Püschel K, Ondruschka B. Über die Ansteckungsgefahr beim Umgang mit SARS-CoV-2-positiven Leichen. Bestattungskultur 2021 Heft 5.
  10. Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033.
  11. Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6.
  12. Bräuninger H, Stoffers B, Fitzek ADE, Meißner K, Aleshcheva G, Schweizer M, Weimann J, Rotter B, Warnke S, Edler C, Braun F, Roedl K, Scherschel K, Escher F, Kluge S, Huber TB, Ondruschka B, Schultheiss HP, Kirchhof P, Blankenberg S, Püschel K, Westermann D, Lindner D. Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart. Cardiovasc Res. 2021 Oct 14:cvab322. doi: 10.1093/cvr/cvab322.
  13. von Stillfried S, Boor P; DeRegCOVID und DEFEAT PANDEMIcs. Entwicklung eines kooperativen Obduktionsnetzwerks aus Pathologie, Neuropathologie und Rechtsmedizin [Development of a cooperative autopsy network of pathology, neuropathology and forensic medicine]. Pathologe. 2021 Oct 29:1–5. German. doi: 10.1007/s00292-021-01004-w.
  14. Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1.
  15. Heinrich F, Nentwich MF, Bibiza-Freiwald E, Nörz D, Roedl K, Christner M, Hoffmann A, Olearo F, Kluge S, Aepfelbacher M, Wichmann D, Lütgehetmann M, Pfefferle S. SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. Open Forum Infect Dis. 2021 Oct 6;8(11):ofab509. doi: 10.1093/ofid/ofab509.
  16. Ondruschka B, Püschel K, Lange P, Becker IK, Rieger-Ndakorerwa G, Schröder AS. SARS-CoV-2-assoziierte Hamburger Sterbefälle in der zweiten Pandemiewelle - Vergleich der bekannt gewordenen Todesfälle in den Gesundheitsämtern und der Rechtsmedizin. Archiv für Kriminologie. 2021 - accepted, in Print
  17. Michel P, Savinsky G, Ondruschka B, Czinczoll I. Folgen einer Reanimation in Zeiten der Pandemie. Hamburger Ärzteblatt. 2021 Nov.
  18. Berezowska S, Boor P, Jonigk D, Tischler V. [Update on thoracic pathology 2021-report of the working group thoracic pathology of the German Society of Pathology]. Pathologe. 2021 Oct 5;1-4. doi: 10.1007/s00292-021-00991-0.
  19. Nörz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7. J Clin Virol. 2021m Aug;141:104894. doi: 10.1016/j.jcv.2021.104894.
  20. Walsh C, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD. Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography. bioRxiv [Preprint]. 2021 Feb 3:2021.02.03.429481. Update in: Nat Methods. 2021 Nov 4 doi: 10.1101/2021.02.03.429481.
  21. Simnica D, Schultheiß C, Mohme M, Paschold L, Willscher E, Fitzek A, Püschel K, Matschke J, Ciesek S, Sedding DG, Zhao Y, Gagliani N, Maringer Y, Walz JS, Heide J, Schulze-Zur-Wiesch J, Binder M. Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts. Clin Transl Immunology. 2021 Aug 28;10(9):e1340. doi: 10.1002/cti2.1340.
  22. Menger J, Apostolidou S, Edler C, Kniep I, Kobbe R, Singer D, Sperhake JP. Fatal outcome of SARS-CoV-2 infection (B1.1.7) in a 4-year-old child. Int J Legal Med. 2021 Sep 12:1–4. doi: 10.1007/s00414-021-02687-9.
  23. Lehmann M, Allers K, Heldt C, Meinhardt J, Schmidt F, Rodriguez-Sillke Y, Kunkel D, Schumann M, Böttcher C, Stahl-Hennig C, Elezkurtaj S, Bojarski C, Radbruch H, Corman VM, Schneider T, Loddenkemper C, Moos V, Weidinger C, Kühl AA, Siegmund B. Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells. Mucosal Immunol. 2021 Aug 21:1–12. doi: 10.1038/s41385-021-00437-z.
  24. Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity. 2021 Jul 13;54(7):1594-1610.e11. doi: 10.1016/j.immuni.2021.06.002.
  25. O'Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, Delgado-Tirado S, Hu X, Chmielewska N, Chandrahas A, Fitzek A, Heinrich F, Steurer S, Ondruschka B, Glatzel M, Krasemann S, Sepulveda-Falla D, Lagares D, Pedron J, Bushweller JH, Liu P, Arboleda-Velasquez JF, Kim LA. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. doi: 10.1016/j.ajpath.2021.04.006.
  26. Edler C, Klein A, Schröder AS, Sperhake JP, Ondruschka B. Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®). Leg Med (Tokyo). 2021 Jul;51:101895. doi: 10.1016/j.legalmed.2021.101895.
  27. Gromniak M, Neidhardt M, Heinemann A, Püschel K, Schlaefer A. "Needle placement accuracy in CT-guided robotic post mortem biopsy: " Current Directions in Biomedical Engineering, vol. 6, no. 1, 2020, pp. 20200031. doi: 10.1515/cdbme-2020-0031.
  28. Gerlach S, Neidhardt M, Weiß T, Laves MH, Stapper C, Gromniak M, Kniep I, Möbius D, Heinemann A, Ondruschka B, Schlaefer A. Needle insertion planning for obstacle avoidance in robotic biopsy. Current Directions in Biomedical Engineering. 2021;7(2): 779-782. doi: 10.1515/cdbme-2021-2199.
  29. Elezkurtaj S, Greuel S, Ihlow J, Michaelis EG, Bischoff P, Kunze CA, Sinn BV, Gerhold M, Hauptmann K, Ingold-Heppner B, Miller F, Herbst H, Corman VM, Martin H, Radbruch H, Heppner FL, Horst D. Causes of death and comorbidities in hospitalized patients with COVID-19. Sci Rep. 2021 Feb 19;11(1):4263. doi: 10.1038/s41598-021-82862-5.
  30. Aschman T, Schneider J, Greuel S, Meinhardt J, Streit S, Goebel HH, Büttnerova I, Elezkurtaj S, Scheibe F, Radke J, Meisel C, Drosten C, Radbruch H, Heppner FL, Corman VM, Stenzel W. Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died. JAMA Neurol. 2021 Aug 1;78(8):948-960. doi: 10.1001/jamaneurol.2021.2004.
  31. Kruse JM, Zickler D, Lüdemann WM, Piper SK, Gotthardt I, Ihlow J, Greuel S, Horst D, Kahl A, Eckardt KU, Elezkurtaj S. Evidence for a thromboembolic pathogenesis of lung cavitations in severely ill COVID-19 patients. Sci Rep. 2021 Aug 6;11(1):16039. doi: 10.1038/s41598-021-95694-0
  32. Verhoff MA, Püschel K, Ondruschka B. SARS-CoV-2: Was bei der Leichenschau infizierter Verstorbener zu beachten ist [Infectiousness of SARS-CoV-2 positive corpses during external post mortem examination]. MMW Fortschr Med. 2021 Jun;163(12):56-58. German. doi: 10.1007/s15006-021-0084-4
  33. Dittmayer C, Meinhardt J, Radbruch H, Radke J, Heppner BI, Heppner FL, Stenzel W, Holland G, Laue M. Using EM data to understand COVID-19 pathophysiology - Authors' reply. Lancet. 2021 Jan 16;397(10270):197-198. doi: 10.1016/S0140-6736(21)00032-5
  34. Ihlow J, Michaelis E, Greuel S, Heynol V, Lehmann A, Radbruch H, Meinhardt J, Miller F, Herbst H, Corman VM, Westermann J, Bullinger L, Horst D, von Brünneck AC, Elezkurtaj S. B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased. Int J Infect Dis. 2021 Feb;103:628-635. doi: 10.1016/j.ijid.2020.12.078
  35. Greuel S, Ihlow J, Dragomir MP, Streit S, Corman VM, Haberbosch L, Winkler D, Meinhardt J, Aschman T, Schneider J, Trotsyuk I, Kunze CA, Maurer L, Radbruch H, Heppner FL, Horst D, Elezkurtaj S. COVID-19: Autopsy findings in six patients between 26 and 46 years of age. Int J Infect Dis. 2021 Jul;108:274-281 doi: 10.1016/j.ijid.2021.05.069
  36. Ihlow J, Seelhoff A, Corman VM, Gruber AD, Dökel S, Meinhardt J, Radbruch H, Späth-Schwalbe E, Elezkurtaj S, Horst D, Herbst H. COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis. BMC Infect Dis. 2021 Sep 3;21(1):901. doi: 10.1186/s12879-021-06605-7
  37. Fitzek A, Schädler J, Dietz E, Ron A, Gerling M, Kammal AL, Lohner L, Falck C, Möbius D, Goebels H, Gerberding AL, Schröder AS, Sperhake JP, Klein A, Fröb D, Mushumba H, Wilmes S, Anders S, Kniep I, Heinrich F, Langenwalder F, Meißner K, Lange P, Zapf A, Püschel K, Heinemann A, Glatzel G, Matschke J, Aepfelbacher M, Lütgehetmann M, Steurer S, Torns C, Edler C, Ondruschka B. Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases. Sci Rep. 2021 Sep 29;11(1):19342. doi: 10.1038/s41598-021-98499-3
  38. Swoboda J, Wittschieber D, Sanft J, Kleemann S, Elschner S, Ihle H, Hubig M, Pletz MW, Mall G, Gassler N. Bone marrow haemophagocytosis indicates severe infection with severe acute respiratory syndrome coronavirus 2. Histopathology. 2021 Apr;78(5):727-737. doi: 10.1111/his.14281
  39. Kaltschmidt B, Fitzek ADE, Schaedler J, Förster C, Kaltschmidt C, Hansen T, Steinfurth F, Windmöller BA, Pilger C, Kong C, Singh K, Nierhaus A, Wichmann D, Sperhake J, Püschel K, Huser T, Krüger M, Robson SC, Wilkens L, Schulte Am Esch J. Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19. Clin Gastroenterol Hepatol. 2021 Aug;19(8):1726-1729.e3. doi: 10.1016/j.cgh.2021.01.044
  40. Kahn M, Schuierer L, Bartenschlager C, Zellmer S, Frey R, Freitag M, Dhillon C, Heier M, Ebigbo A, Denzel C, Temizel S, Messmann H, Wehler M, Hoffmann R, Kling E, Römmele C. Performance of antigen testing for diagnosis of COVID-19: a direct comparison of a lateral flow device to nucleic acid amplification based tests. BMC Infect Dis. 2021 Aug 10;21(1):798. doi: 10.1186/s12879-021-06524-7
  41. Rank A, Tzortzini A, Kling E, Schmid C, Claus R, Löll E, Burger R, Römmele C, Dhillon C, Müller K, Girl P, Hoffmann R, Grützner S, Dennehy KM. One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms. J Clin Med. 2021 Jul 27;10(15):3305. doi: 10.3390/jcm10153305
  42. Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchón FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, Höfer A, Kühnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, Pfeffer TJ, Hilfiker A, Haverich A, Hilfiker-Kleiner D. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLoS One. 2021 Aug 4;16(8):e0255335. doi: 10.1371/journal.pone.0255335
  43. Ackermann M, Jonigk DD. Microvascular placental alterations in maternal COVID-19. Am J Obstet Gynecol. 2021 Jul 3:S0002-9378(21)00782-1. doi: 10.1016/j.ajog.2021.06.098
  44. Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kümpers P, Skurnik D, Randi AM, Griffioen AW. COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. 2021 Jun 28:1–34. doi: 10.1007/s10456-021-09805-6
  45. Hansen T, Titze U, Kulamadayil-Heidenreich NSA, Glombitza S, Tebbe JJ, Röcken C, Schulz B, Weise M, Wilkens L. First case of postmortem study in a patient vaccinated against SARS-CoV-2. Int J Infect Dis. 2021 Jun;107:172-175. doi: 10.1016/j.ijid.2021.04.053
  46. Guarino M, Cossiga V, Esposito I, Alessandro F, Morisco F. Effectiveness of SARS-Cov-2 vaccination in liver transplanted patients: the debate is open! J Hepatol. 2021 Aug 3:S0168-8278(21)01961-9. doi: 10.1016/j.jhep.2021.07.034
  47. Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T. Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica. 2021 Aug 1;106(8):2170-2179. doi: 10.3324/haematol.2021.279000
  48. Ondruschka B, Heinrich F, Lindenmeyer M, Edler C, Möbius D, Czogalla J, Heinemann A, Braun F, Aepfelbacher M, Lütgehetmann M, Huber TB. Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7. Int J Legal Med. 2021 Sep 6:1–3. doi: 10.1007/s00414-021-02691-z
  49. Gagiannis D, Umathum VG, Bloch W, Rother C, Stahl M, Witte HM, Djudjaj S, Boor P, Steinestel K. Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2. Am J Clin Pathol. 2021. doi: 10.1093/ajcp/aqab087
  50. Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM, Wucherpfennig S, Cacchi C, Braunschweig T, Knüchel-Clarke R, Jonigk D, Werlein C, Bülow RD, Dahl E, von Stillfried S, Boor P. Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients. Cells. 2021;10(8):1900. doi: 10.3390/cells10081900
  51. von Stillfried S, Villwock S, Bülow RD, Djudjaj S, Buhl EM, Maurer A, Ortiz-Brüchle N, Celec P, Klinkhammer BM, Wong DWL, Cacchi C, Braunschweig T, Knüchel-Clarke R, Dahl E, Boor P. SARS-CoV-2 RNA screening in routine pathology specimens. Microb Biotechnol. 2021 Jul;14(4):1627-1641. doi: 10.1111/1751-7915.13828
  52. Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, Glatzel M, Nörz D, Günther T, Czech-Sioli M, Fischer N, Grundhoff A, Lütgehetmann M, Ondruschka B. Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant. Int J Legal Med. 2021 Jun 5:1–10. doi: 10.1007/s00414-021-02618-8
  53. Schröder AS, Edler C, Ondruschka B, Püschel K, Schädler J, Heinemann A, Heinrich F, Lütgehetmann M, Pfefferle S, Aepfelbacher M, Fitzek A, Sperhake JP. The handling of SARS-CoV-2 associated deaths - infectivity of the body. Forensic Sci Med Pathol. 2021 Jun 2:1–8. doi: 10.1007/s12024-021-00379-9
  54. Nörz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, Lütgehetmann M. Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay. J Mol Diagn. 2021 Jun;23(6):777-778. doi: 10.1016/j.jmoldx.2021.03.007
  55. Tampe D, Hakroush S, Bösherz MS, Franz J, Hofmann-Winkler H, Pöhlmann S, Kluge S, Moerer O, Stadelmann C, Ströbel P, Winkler MS, Tampe B. Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. Front Med (Lausanne). 2021 May 25;8:644715. doi: 10.3389/fmed.2021.644715
  56. Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T. Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia. Haematologica. 2021 May 20. doi: 10.3324/haematol.2021.279000
  57. Roedl K, Heidenreich S, Pfefferle S, Jarczak D, Urbanowicz TT, Nörz D, Aepfelbacher M, Kröger N, Kluge S, Lütgehetmann M, Christopeit M, Wichmann D. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19. Am J Respir Crit Care Med. 2021 15;203(2):242-245. doi: 10.1164/rccm.202009-3386LE
  58. Bayyoud T, Iftner A, Iftner T, Bartz-Schmidt KU, Ziemssen F, Bösmüller H, Fend F, Rohrbach JM, Ueffing M, Schindler M, Thaler S. Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina? PLoS One. 2021 May 13;16(5):e0251682. doi: 10.1371/journal.pone.0251682
  59. Englert H, Rangaswamy C, Deppermann C, Sperhake JP, Krisp C, Schreier D, Gordon E, Konrath S, Haddad M, Pula G, Mailer RK, Schlüter H, Kluge S, Langer F, Püschel K, Panousis K, Stavrou EX, Maas C, Renné T, Frye M. Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine. 2021 May;67:103382. doi: 10.1016/j.ebiom.2021.103382
  60. Klein A, Langenwalder F, Heinrich F, Meißner K, Schröder AS, Püschel K, Ondruschka B, Lütgehetmann M, Heinemann A. SARS-CoV‑2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020 [SARS-CoV‑2 incidental findings among Hamburg deaths: an epidemiological monitoring during the dynamic infection event in spring 2020]. Rechtsmedizin (Berl). 2021 Apr 20:1-7. German. doi: 10.1007/s00194-021-00481-w
  61. Hansen T, Titze U, Kulamadayil-Heidenreich NSA, Glombitza S, Tebbe JJ, Röcken C, Schulz B, Weise M, Wilkens L. First case of postmortem study in a patient vaccinated against SARS CoV2. Int J Infect Dis. 2021 Apr 16;107:172–5. doi: 10.1016/j.ijid.2021.04.053
  62. Glatzel M, Hagel C, Matschke J, Sperhake J, Deigendesch N, Tzankov A, Frank S. Neuropathology associated with SARS-CoV-2 infection. Lancet. 2021 23;397(10271):276. doi: 10.1016/S0140-6736(21)00098-2
  63. Lohner L, Fröb D, Edler C, Schröder AS, Dietz E, Ondruschka B. SARS-CoV-2-assoziierte Todesfälle von erwachsenen Personen bis 50 Jahre: Eine retrospektive Auswertung der COVID-19-assoziierten Todesfälle im Jahr 2020 im Institut für Rechtsmedizin Hamburg, Deutschland [SARS-CoV-2-associated deaths in adult persons up to 50 years of age]. Rechtsmedizin (Berl). 2021 Apr 13:1-9. German. doi: 10.1007/s00194-021-00483-8
  64. Casagrande M, Fitzek A, Spitzer M, Püschel K, Glatzel M, Krasemann S, Aepfelbacher M, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M. Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19. Br J Ophthalmol. 2021 Apr 9:bjophthalmol-2020-318618. doi: 10.1136/bjophthalmol-2020-318618
  65. Hajek A, Bertram F, Heinrich F, van Rüth V, Ondruschka B, Kretzler B, Schüler C, Püschel K, König HH. Determinants of health care use among homeless individuals: evidence from the Hamburg survey of homeless individuals. BMC Health Serv Res. 2021 Apr 7;21(1):317. doi: 10.1186/s12913-021-06314-6
  66. Olearo F, Nörz D, Heinrich F, Sutter JP, Roedl K, Schultze A, Wiesch JSZ, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR. J Clin Virol. 2021 Apr;137:104782. doi: 10.1016/j.jcv.2021.104782
  67. Zack F, Nigbur S, Manhart J, Derani H, Boy D, Kolbe V, Büttner A. Erste Ergebnisse der Obduktionen der im Zusammenhang mit den SARS-CoV-2-Infektionen Verstorbenen aus der Unimedizin Rostock. Ärztebl Meckl-Vorpom. 2021 Apr; 31:125-128.
  68. Bertram F, Heinrich F, Fröb D, Wulff B, Ondruschka B, Püschel K, König HH, Hajek A. Loneliness among Homeless Individuals during the First Wave of the COVID-19 Pandemic. Int J Environ Res Public Health. 2021 16;18(6):3035. doi: 10.3390/ijerph18063035
  69. Subbarayan K, Ulagappan K, Wickenhauser C, Bachmann M, Seliger B. Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues. Front Immunol. 2021 16;12:597399. doi: 10.3389/fimmu.2021.597399
  70. Ackermann M, Werlein C, Länger F, Kühnel MP, Jonigk DD. COVID-19: Auswirkungen auf Lunge und Herz [COVID-19: effects on the lungs and heart]. Pathologe. 2021 Mar;42(2):164-171. German. doi: 10.1007/s00292-021-00918-9
  71. Amann K, Boor P, Wiech T, Singh J, Vonbrunn E, Knöll A, Hermann M, Büttner-Herold M, Daniel C, Hartmann A. COVID-19-Auswirkungen auf die Niere [COVID-19 effects on the kidney]. Pathologe. 2021 Mar;42(2):183-187. German. doi: 10.1007/s00292-020-00899-1
  72. Boor P, Eichhorn P, Hartmann A, Lax SF, Märkl B, Menter T, Skok K, Slotta-Huspenina J, von Stillfried S, Tzankov A, Weirich G. Praktische Aspekte von COVID-19-Obduktionen [Practical aspects of COVID-19 autopsies]. Pathologe. 2021 Mar;42(2):197-207. German. doi: 10.1007/s00292-021-00925-w
  73. Ritschel N, Radbruch H, Herden C, Schneider N, Dittmayer C, Franz J, Thomas C, Silva Boos G, Pagenstecher A, Schulz-Schaeffer W, Stadelmann C, Glatzel M, Heppner FL, Weis J, Sohrabi K, Schänzer A, Németh A, Acker T; DGNN-Taskforce „CNS-COVID19“; „DEFEAT PANDEMIcs – Neuropathologische Referenzdiagnostik bei COVID-19“. COVID-19: Auswirkungen auf das zentrale und periphere Nervensystem [COVID-19 and the central and peripheral nervous system]. Pathologe. 2021 Mar;42(2):172-182. German. doi: 10.1007/s00292-021-00924-x
  74. Roth W, Boor P. COVID-19 im Spiegel der Pathologie [COVID-19 in the mirror of pathology]. Pathologe. 2021 Mar;42(2):147-148. German. doi: 10.1007/s00292-021-00916-x
  75. Strobl S, Roth W. Internationale wissenschaftliche Publikationsaktivität zu COVID-19 [International publication activity during the COVID-19 pandemic]. Pathologe. 2021 Mar;42(2):224-230. German. doi: 10.1007/s00292-020-00892-8
  76. Traxler S, Schindler M, Bösmüller H, Klingel K. Biologie und Pathologie von Coronaviren [Biology and pathology of coronaviruses]. Pathologe. 2021; 42(2):149-154. German. doi: 10.1007/s00292-021-00923-y
  77. von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bülow RD, Bürrig KF, Holtherm HU, Jonigk D, Knüchel R, Majeed RW, Röhrig R, Wienströer J, Boor P. Kooperatives Vorgehen der Pathologie und Neuropathologie in der COVID-19-Pandemie : Deutsches Register für COVID-19-Obduktionen (DeRegCOVID) und Deutsches Netzwerk für Autopsien in Pandemien (DEFEAT PANDEMIcs) [Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs)]. Pathologe. 2021 Mar;42(2):216-223. German. doi: 10.1007/s00292-020-00891-9
  78. von Stillfried S, Boor P. Nachweismethoden von SARS-CoV-2 in Gewebe [Methods of SARS-CoV-2 detection in tissue]. Pathologe. 2021 Mar;42(2):208-215. German. doi: 10.1007/s00292-021-00919-8
  79. Englisch CN, Tschernig T, Flockerzi F, Meier C, Bohle RM. Lesions in the lungs of fatal corona virus disease Covid-19. Ann Anat. 2021 Mar;234:151657. doi: 10.1016/j.aanat.2020.151657
  80. Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Häberle H, Mehrländer M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bösmüller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger P. Antibody-induced procoagulant platelets in severe COVID-19 infection. Blood. 2021 Feb 25;137(8):1061-1071. doi: 10.1182/blood.2020008762
  81. Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF. Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. Sci Immunol. 2021 23;6(56):eabf6692. doi: 10.1126/sciimmunol.abf6692
  82. Spogis J, Hagen F, Thaiss WM, Hoffmann T, Malek N, Nikolaou K, Berg CP, Singer S, Bösmüller H, Kreth F, Kaufmann S. Sonographic findings in coronavirus disease-19 associated liver damage. PLoS One. 2021 Feb 19;16(2):e0244781. doi: 10.1371/journal.pone.0244781
  83. Kniep I, Heinemann A, Edler C, Sperhake JP, Püschel K, Ondruschka B, Schröder AS. COVID-19 lungs in post-mortem computed tomography. Rechtsmedizin (Berl). 2021 15:1-3. doi: 10.1007/s00194-021-00462-z
  84. Hofman P, Ilié M, Chamorey E, Brest P, Schiappa R, Nakache V, Antoine M, Barberis M, Begueret H, Bibeau F, Bonnetaud C, Boström P, Brousset P, Bubendorf L, Carvalho L, Cathomas G, Cazes A, Chalabreysse L, Chenard MP, Copin MC, Côté JF, Damotte D, de Leval L, Delongova P, Thomas de Montpreville V, de Muret A, Dema A, Dietmaier W, Evert M, Fabre A, Forest F, Foulet A, Garcia S, Garcia-Martos M, Gibault L, Gorkiewicz G, Jonigk D, Gosney J, Hofman A, Kern I, Kerr K, Kossai M, Kriegsmann M, Lassalle S, Long-Mira E, Lupo A, Mamilos A, Matěj R, Meilleroux J, Ortiz-Villalón C, Panico L, Panizo A, Papotti M, Pauwels P, Pelosi G, Penault-Llorca F, Pop O, Poté N, Cajal SRY, Sabourin JC, Salmon I, Sajin M, Savic-Prince S, Schildhaus HU, Schirmacher P, Serre I, Shaw E, Sizaret D, Stenzinger A, Stojsic J, Thunnissen E, Timens W, Troncone G, Werlein C, Wolff H, Berthet JP, Benzaquen J, Marquette CH, Hofman V, Calabrese F. Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future. ESMO Open. 2021 Feb;6(1):100024. doi: 10.1016/j.esmoop.2020.100024.
  85. Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Gelderblom HR, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Scheibe F, Körtvélyessy P, Reinhold D, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Ingold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021 Feb;24(2):168-175. doi: 10.1038/s41593-020-00758-5
  86. Nicolai L, Leunig A, Brambs S, Kaiser R, Joppich M, Hoffknecht ML, Gold C, Engel A, Polewka V, Muenchhoff M, Hellmuth JC, Ruhle A, Ledderose S, Weinberger T, Schulz H, Scherer C, Rudelius M, Zoller M, Keppler OT, Zwißler B, von Bergwelt-Baildon M, Kääb S, Zimmer R, Bülow RD, von Stillfried S, Boor P, Massberg S, Pekayvaz K, Stark K. Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia. J Thromb Haemost. 2021 Feb;19(2):574-581. doi: 10.1111/jth.15179
  87. Nörz D, Hoffmann A, Aepfelbacher M, Pfefferle S, Lütgehetmann M. Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform. J Med Microbiol. 2021;70(2):001295. doi: 10.1099/jmm.0.001295
  88. Kaltschmidt B, Fitzek ADE, Schaedler J, Förster C, Kaltschmidt C, Hansen T, Steinfurth F, Windmöller BA, Pilger C, Kong C, Singh K, Nierhaus A, Wichmann D, Sperhake J, Püschel K, Huser T, Krüger M, Robson SC, Wilkens L, Schulte Am Esch J. Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19. Clin Gastroenterol Hepatol. 2021 29:S1542-3565(21)00094-X. doi: 10.1016/j.cgh.2021.01.044
  89. Casagrande M, Fitzek A, Spitzer MS, Püschel K, Glatzel M, Krasemann S, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M. Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19. JAMA Ophthalmol. 2021 21:e206339. doi: 10.1001/jamaophthalmol.2020.6339
  90. Evert K, Dienemann T, Brochhausen C, Lunz D, Lubnow M, Ritzka M, Keil F, Trummer M, Scheiter A, Salzberger B, Reischl U, Boor P, Gessner A, Jantsch J, Calvisi DF, Evert M, Schmidt B, Simon M. Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation. Virchows Arch. 2021 Jan 20:1–12. doi: 10.1007/s00428-020-03014-0
  91. Mueller KAL, Langnau C, Günter M, Pöschel S, Gekeler S, Petersen-Uribe Á, Kreisselmeier KP, Klingel K, Bösmüller H, Li B, Jaeger P, Castor T, Rath D, Gawaz MP, Autenrieth SE. Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection. Cardiovasc Res. 2021 Jan 1;117(1):224-239. doi: 10.1093/cvr/cvaa328
  92. Heinrich F, Meißner K, Langenwalder F, Püschel K, Nörz D, Hoffmann A, Lütgehetmann M, Aepfelbacher M, Bibiza-Freiwald E, Pfefferle S, Heinemann A. Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa. Emerg Infect Dis. 2021;27(1):329–31. doi:10.3201/eid2701.203112
  93. Bösmüller H, Matter M, Fend F, Tzankov A. The pulmonary pathology of COVID-19. Virchows Arch. 2021 Jan;478(1):137-150. doi:10.1007/s00428-021-03053-1
  94. Janíková M, Hodosy J, Boor P, Klempa B, Celec P. Loop-mediated isothermal amplification for the detection of SARS-CoV-2 in saliva. Microb Biotechnol. 2021 Jan;14(1):307-316. doi: 10.1111/1751-7915.13737
  95. Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch JK, Lütgehetmann M, Fischer N. SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany. Clin Microbiol Infect. 2021;27(1):130.e5-130.e8. doi: 10.1016/j.cmi.2020.09.034
  1. Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 13;370(6518):856-860. doi: 10.1126/science.abd2985
  2. Subbarayan K, Ulagappan K, Wickenhauser C, Seliger B. Expression and clinical significance of SARS-CoV-2 human targets in neoplastic and non-neoplastic lung tissues. Curr Cancer Drug Targets. 2020 7. doi: 10.2174/1568009620666201207145019
  3. Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovasc Res. 2020 Dec 1;116(14):2207-2215. doi: 10.1093/cvr/cvaa267
  4. Boor P, Hartmann A. Bericht zur Late-Breaking Session Pathologie und COVID-19 [Late Breaking Session Pathology and COVID-19 Report]. Pathologe. 2020 Dec;41(Suppl 2):96-98. German. doi: 10.1007/s00292-020-00882-w
  5. Hüppe D, Niederau C, Serfert Y, Hartmann H, Wedemeyer H; für das DHC-R. Versorgungsprobleme von Patienten mit chronischer Hepatitis C während der COVID-19-Pandemie und der Lockdown-Verordnungen [Problems in treating patients with chronic HCV infection due to the COVID-19 pandemic and during the lockdown phase in Germany]. Z Gastroenterol. 2020 Dec;58(12):1182-1185. German. doi: 10.1055/a-1291-8518
  6. Lauermann P, Storch M, Weig M, Tampe B, Winkler M, Hoerauf H, Feltgen N, Hakroush S. There is no intraocular affection on a SARS-CoV-2 - Infected ocular surface. Am J Ophthalmol Case Rep. 2020 ;20:100884. doi: 10.1016/j.ajoc.2020.100884
  7. Lang P, Eichholz T, Bakchoul T, Streiter M, Petrasch M, Bösmüller H, Klein R, Rabsteyn A, Lang AM, Adams C, Klingel K, Gessner M, Rosenberger P, Ruef P, Handgretinger R. Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):622-625. doi: 10.1093/jpids/piaa117
  8. Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, Scherschel K, Kirchhof P, Escher F, Schultheiss HP, Blankenberg S, Püschel K, Westermann D. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol. 2020 Nov 1;5(11):1281-1285. doi: 10.1001/jamacardio.2020.3551
  9. Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, Püschel K, Krasemann S, Aepfelbacher M, Glatzel M. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020 Nov;19(11):919-929. doi: 10.1016/S1474-4422(20)30308-2
  10. Sperhake JP. Autopsies of COVID-19 deceased? Absolutely! Leg Med (Tokyo). 2020 Nov;47:101769. doi: 10.1016/j.legalmed.2020.101769
  11. Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Münch C, Wass MN, Michaelis M, Cinatl J Jr. Aprotinin Inhibits SARS-CoV-2 Replication. Cells. 2020 Oct 30;9(11):2377. doi: 10.3390/cells9112377
  12. Schrappe M, François-Kettner H, Gruhl M, Hart D, Knieps F, Manow P, Pfaff H, Püschel K, Glaeske G. Die Pandemie durch SARS-CoV-2/Covid-19 –der Übergang zur chronischen Phase. MVF. 2020 Oct 8;5:35-68. doi: 10.24945/MVF.05.20.1866-0533.2253
  13. Trigaux C, Salla S, Schroeter J, Tourtas T, Thomasen H, Maier P, Hellwinkel OJC, Wittmershaus I, Merz PR, Seitz B, Nölle B, Schrage N, Roters S, Apel M, Gareiss-Lok A, Uhlig CE, Thaler S, Raber F, Kampik D, Geerling G, Menzel-Severing J. SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks. Curr Eye Res. 2020 Oct 4:1-6. doi: 10.1080/02713683.2020.1828487
  14. Gagiannis D, Steinestel J, Hackenbroch C, Schreiner B, Hannemann M, Bloch W, Umathum VG, Gebauer N, Rother C, Stahl M, Witte HM, Steinestel K. Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD). Front Immunol. 2020 Oct 2;11:587517. doi: 10.3389/fimmu.2020.587517
  15. Goebels H, Edler C, Fitzek A, Schädler J, Schröder AS, Kniep I, Püschel K. Obduktion bei Covid-19. Pathologische Veränderungen und Organmanifestationen. Klinikarzt. 2020 Oct 1;49(10):404-408. doi: 10.1055/a-1260-9966
  16. Wiech T, Sperhake J, Zipfel P, Huber T. Nierenpathologische Befunde bei COVID-19-Patienten. Mechanismen des Nierenversagens und histopathologische Veränderungen. Klinikarzt. 2020 Oct 1;49(10):425-428. doi: 10.1055/a-1262-0048
  17. Kniep I, Lutter M, Ron A, Edler C, Püschel K, Ittrich H, Heller M, Heinemann A. Postmortale Bildgebung der Lunge bei COVID-19-Todesfällen [Postmortem imaging of the lung in cases of COVID-19 deaths]. Radiologe. 2020 Oct;60(10):927-933. German. doi: 10.1007/s00117-020-00733-y
  18. Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, Scherer C, Rudelius M, Zoller M, Höchter D, Keppler O, Teupser D, Zwißler B, von Bergwelt-Baildon M, Kääb S, Massberg S, Pekayvaz K, Stark K. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy. Circulation. 2020 Sep 22;142(12):1176-1189. doi: 10.1161/CIRCULATIONAHA.120.048488
  19. Wagner WL, Hellbach K, Fiedler MO, Salg GA, Wehrse E, Ziener CH, Merle U, Eckert C, Weber TF, Stiller W, Wielpütz MO, Dullin C, Kenngott HG, Schlemmer HP, Weigand MA, Schirmacher P, Longerich T, Kauczor HU, Kommoss FK, Schwab C. Mikrovaskuläre Veränderungen bei COVID-19 [Microvascular changes in COVID-19]. Radiologe. 2020;60(10):934-942. German. doi: 10.1007/s00117-020-00743-w
  20. Bösmüller H, Traxler S, Bitzer M, Häberle H, Raiser W, Nann D, Frauenfeld L, Vogelsberg A, Klingel K, Fend F. The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. Virchows Arch. 2020 Sep;477(3):349-357. doi: 10.1007/s00428-020-02881-x
  21. Heinrich F, Sperhake JP, Heinemann A, Mushumba H, Lennartz M, Nörz D, Glatzel M, Lütgehetmann M, Püschel K. Germany's first COVID-19 deceased: a 59-year-old man presenting with diffuse alveolar damage due to SARS-CoV-2 infection. Virchows Arch. 2020 Sep;477(3):335-339. doi: 10.1007/s00428-020-02872-y
  22. Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet. 2020 Aug 29;396(10251):597-598. doi: 10.1016/S0140-6736(20)31759-1
  23. Fuest M, Boor P, Knuechel R; DeRegCOVID, Walter P, Salla S. Postmortem conjunctival and nasopharyngeal swabs in SARS-CoV-2 infected and uninfected patients. Acta Ophthalmol. 2020 Aug 6:10.1111/aos.14559. doi: 10.1111/aos.14559
  24. Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, Tzankov A, Werlein C, Kühnel M, Jonigk D, Salditt T. 3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography. Elife. 2020 Aug 20;9:e60408. doi: 10.7554/eLife.60408
  25. Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Ann Intern Med. 2020 Aug 18;173(4):268-277. doi: 10.7326/M20-2003.
  26. von Stillfried S, Bülow RD, Röhrig R, Knüchel-Clarke R, Boor P; DeRegCOVID. Autopsy registry can facilitate COVID-19 research. EMBO Mol Med. 2020 Aug 7;12(8):e12885. doi: 10.15252/emmm.202012885
  27. Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med. 2020 Aug 6;383(6):590-592. doi: 10.1056/NEJMc2011400
  28. Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Stürzl M, Staats L, Mahajan A, Schauer C, Kremer AN, Völkl S, Amann K, Evert K, Falkeis C, Wehrfritz A, Rieker RJ, Hartmann A, Kremer AE, Neurath MF, Muñoz LE, Schett G, Herrmann M. Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine. 2020;58:102925. doi: 10.1016/j.ebiom.2020.102925
  29. Kommoss FKF, Schwab C, Tavernar L, Schreck J, Wagner WL, Merle U, Jonigk D, Schirmacher P, Longerich T. The Pathology of Severe COVID-19-Related Lung Damage. Dtsch Arztebl Int. 2020 Jul 20;117(29-30):500-506. doi: 10.3238/arztebl.2020.0500
  30. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020 Jul 9;383(2):120-128. doi: 10.1056/NEJMoa2015432
  31. Klein A, Edler C, Fitzek A, et al. Der erste COVID-19-Hotspot in einer Hamburger Senioreneinrichtung: Präventionskonzept, Letalität und Obduktionsbefunde [The first COVID-19 hotspot in a retirement home in Hamburg] [published online ahead of print, 2020 Jul 5]. Rechtsmedizin (Berl). 2020;1-7.
  32. Casagrande M, Fitzek A, Püschel K, Aleshcheva G, Schultheiss HP, Berneking L, Spitzer MS, Schultheiss M. Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients. Ocul Immunol Inflamm. 2020 Jul 3;28(5):721-725. doi: 10.1080/09273948.2020.1770301
  33. Edler C, Schröder AS, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, Klein A, Langenwalder F, Lütgehetmann M, Meißner K, Püschel K, Schädler J, Steurer S, Mushumba H, Sperhake JP. Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany. Int J Legal Med. 2020 Jul;134(4):1275-1284. doi: 10.1007/s00414-020-02317-w
  34. Püschel K, Sperhake JP. Corona deaths in Hamburg, Germany. Int J Legal Med. 2020 Jul;134(4):1267-1269. doi: 10.1007/s00414-020-02332-x
  35. Schreck J, Baretton G, Schirmacher P. Situation der Deutschen Universitätspathologien unter den Einschränkungen der Corona-Pandemie – Auswertung einer ersten repräsentativen Umfrage [Situation of the German university pathologies under the constraints of the corona pandemic-evaluation of a first representative survey]. Pathologe. 2020 Jul;41(4):400-405. German. doi: 10.1007/s00292-020-00791-y
  36. Schädler J, Gerling M, Edler C. Covid-19-Pneumonie und rezidivierende Lungenembolie. Hamburger Ärzteblatt. 2020 Jun;73(6):36-37.
  37. Püschel K, Kluge S, Addo M, Aepfelbacher M. Von den Toten lernen-neue Erkenntnisse zu Covid-19. Hamburger Ärzteblatt. 2020 Jun;73(6):34-36.
  38. Ramsthaler F, Heinbuch S, Schmidt PH, Bohle RM, Rissland J, Gärtner B, Verhoff MA, Kettner M, Potente S. Aktuelle Empfehlungen zum Umgang mit dem Verdacht auf COVID-19 in der rechtsmedizinischen Routine. Archiv für Kriminologie. 2020 Jun;245:50-63.
  39. Fitzek A, Sperhake J, Edler C, Schröder AS, Heinemann A, Heinrich F, Ron A, Mushumba H, Lütgehetmann M, Püschel K. Evidence for systematic autopsies in COVID-19 positive deceased: Case report of the first German investigated COVID-19 death. Rechtsmedizin (Berl). 2020 May 25:1-6. doi: 10.1007/s00194-020-00401-4
  40. Püschel K, Frenkel A, Mull G, Birkholz H, Hengfoss C. Einsatz von Fieberkameras zum Schutz vor COVID-19. Der Kriminalist. 2020;11:29-32.
  41. Ron A, Püschel K. Todesursachen im Zusammenhang mit Infektionen durch SARS-CoV-2. WUNDmanagement. 2020;14(3):133-135.

© 2023 NATON

Contact
Imprint