2023
5085390
VQGBAU68
items
1
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default
asc
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https://naton.network/wp-content/plugins/zotpress/
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22Benno%22%2C%22lastName%22%3A%22Schreiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Hannemann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wilhelm%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%20G.%22%2C%22lastName%22%3A%22Umathum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niklas%22%2C%22lastName%22%3A%22Gebauer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Conn%22%2C%22lastName%22%3A%22Rother%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcel%22%2C%22lastName%22%3A%22Stahl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanno%20M.%22%2C%22lastName%22%3A%22Witte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konrad%22%2C%22lastName%22%3A%22Steinestel%22%7D%5D%2C%22abstractNote%22%3A%22Background%20and%20ObjectivesUnderstanding%20the%20pathophysiology%20of%20respiratory%20failure%20in%20coronavirus%20disease%202019%20%28COVID-19%29%20is%20indispensable%20for%20development%20of%20therapeutic%20strategies.%20Since%20we%20observed%20similarities%20between%20COVID-19%20and%20interstitial%20lung%20disease%20in%20connective%20tissue%20disease%20%28CTD-ILD%29%2C%20we%20investigated%20features%20of%20autoimmunity%20in%20SARS-CoV-2-associated%20respiratory%20failure.MethodsWe%20prospectively%20enrolled%2022%20patients%20with%20RT-PCR-confirmed%20SARS-CoV-2%20infection%20and%2010%20patients%20with%20non-COVID-19-associated%20pneumonia.%20Full%20laboratory%20testing%20was%20performed%20including%20autoantibody%20%28AAB%3B%20ANA%5C%2FENA%29%20screening%20using%20indirect%20immunofluorescence%20and%20immunoblot.%20Fifteen%20COVID-19%20patients%20underwent%20high-resolution%20computed%20tomography.%20Transbronchial%20biopsies%5C%2Fautopsy%20tissue%20samples%20for%20histopathology%20and%20ultrastructural%20analyses%20were%20obtained%20from%204%5C%2F3%20cases%2C%20respectively.ResultsThirteen%20%2859.1%25%29%20patients%20developed%20acute%20respiratory%20distress%20syndrome%20%28ARDS%29%2C%20and%20five%20patients%20%2822.7%25%29%20died%20from%20the%20disease.%20ANA%20titers%20%5Cu22651%3A320%20and%5C%2For%20positive%20ENA%20immunoblots%20were%20detected%20in%2011%5C%2F13%20%2884.6%25%29%20COVID-19%20patients%20with%20ARDS%2C%20in%201%5C%2F9%20%2811.1%25%29%20COVID-19%20patients%20without%20ARDS%20%28p%20%3D%200.002%29%20and%20in%204%5C%2F10%20%2840%25%29%20patients%20with%20non-COVID-19-associated%20pneumonias%20%28p%20%3D%200.039%29.%20Detection%20of%20AABs%20was%20significantly%20associated%20with%20a%20need%20for%20intensive%20care%20treatment%20%2883.3%20vs.%2010%25%3B%20p%20%3D%200.002%29%20and%20occurrence%20of%20severe%20complications%20%2875%20vs.%2020%25%2C%20p%20%3D%200.03%29.%20Radiological%20and%20histopathological%20findings%20were%20highly%20heterogeneous%20including%20patterns%20reminiscent%20of%20exacerbating%20CTD-ILD%2C%20while%20ultrastructural%20analyses%20revealed%20interstitial%20thickening%2C%20fibroblast%20activation%2C%20and%20deposition%20of%20collagen%20fibrils.ConclusionsWe%20are%20the%20first%20to%20report%20overlapping%20clinical%2C%20serological%2C%20and%20imaging%20features%20between%20severe%20COVID-19%20and%20acute%20exacerbation%20of%20CTD-ILD.%20Our%20findings%20indicate%20that%20autoimmune%20mechanisms%20determine%20both%20clinical%20course%20and%20long-term%20sequelae%20after%20SARS-CoV-2%20infection%2C%20and%20the%20presence%20of%20autoantibodies%20might%20predict%20adverse%20clinical%20course%20in%20COVID-19%20patients.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22ISSN%22%3A%221664-3224%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffimmu.2020.587517%22%2C%22collections%22%3A%5B%228BZR5BXE%22%5D%2C%22dateModified%22%3A%222023-06-06T09%3A15%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22LCKVYDB4%22%2C%22library%22%3A%7B%22id%22%3A5085390%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ackermann%20et%20al.%22%2C%22parsedDate%22%3A%222020-07-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%20style%3D%5C%22clear%3A%20left%3B%20%5C%22%3E%5Cn%20%20%20%20%3Cdiv%20class%3D%5C%22csl-left-margin%5C%22%20style%3D%5C%22float%3A%20left%3B%20padding-right%3A%200.5em%3B%20text-align%3A%20right%3B%20width%3A%201em%3B%5C%22%3E1.%3C%5C%2Fdiv%3E%3Cdiv%20class%3D%5C%22csl-right-inline%5C%22%20style%3D%5C%22margin%3A%200%20.4em%200%201.5em%3B%5C%22%3EAckermann%2C%20M.%2C%20Verleden%2C%20S.%20E.%2C%20Kuehnel%2C%20M.%2C%20Haverich%2C%20A.%2C%20Welte%2C%20T.%2C%20Laenger%2C%20F.%2C%20Vanstapel%2C%20A.%2C%20Werlein%2C%20C.%2C%20Stark%2C%20H.%2C%20Tzankov%2C%20A.%2C%20Li%2C%20W.%20W.%2C%20Li%2C%20V.%20W.%2C%20Mentzer%2C%20S.%20J.%20%26amp%3B%20Jonigk%2C%20D.%20P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