Publications

2024
[1]
Petrov L, Brumhard S, Wisniewski S, Georg P, Hillus D, Hiller A, et al. Rewired type I IFN signaling is linked to age-dependent differences in COVID-19 2024. https://doi.org/10.1101/2024.10.23.619479.
[1]
Zhou L, Pereiro MT, Li Y, Derigs M, Kuenne C, Hielscher T, et al. Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. Sci Transl Med 2024;16:eadk5005. https://doi.org/10.1126/scitranslmed.adk5005.
[1]
Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, et al. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature 2024;631:645–53. https://doi.org/10.1038/s41586-024-07671-y.
[1]
Schwabenland M, Hasavci D, Frase S, Wolf K, Deigendesch N, Buescher JM, et al. High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains. Acta Neuropathol 2024;148:11. https://doi.org/10.1007/s00401-024-02770-6.
[1]
Misailovski M, Koller D, Blaschke S, Berens M, Köster AM, Strobl R, et al. Refining the hospitalization rate: A mixed methods approach to differentiate primary COVID-19 from incidental cases. Infection Prevention in Practice 2024;6:100371. https://doi.org/10.1016/j.infpip.2024.100371.
[1]
Meinhardt J, Streit S, Dittmayer C, Manitius R v, Radbruch H, Heppner FL. The neurobiology of SARS-CoV-2 infection. Nat Rev Neurosci 2024;25:30–42. https://doi.org/10.1038/s41583-023-00769-8.
[1]
Radke J, Meinhardt J, Aschman T, Chua RL, Farztdinov V, Lukassen S, et al. Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19. Nat Neurosci 2024;27:409–20. https://doi.org/10.1038/s41593-024-01573-y.
[1]
Windeck S, Allgoewer K, von Stillfried S, Triefenbach L, Nienaber U, Bülow RD, et al. Entwicklung und Fortschritte des Nationalen Obduktionsnetzwerks (NATON). Pathologie 2024. https://doi.org/10.1007/s00292-024-01307-8.
[1]
Mohme M, Schultheiß C, Piffko A, Fitzek A, Paschold L, Thiele B, et al. SARS-CoV-2-associated T-cell infiltration in the central nervous system. Clinical & Translational Immunology 2024;13:e1487. https://doi.org/10.1002/cti2.1487.
[1]
Lahmer T, Weirich G, Porubsky S, Rasch S, Kammerstetter FA, Schustetter C, et al. Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU. Diagnostics 2024;14:294. https://doi.org/10.3390/diagnostics14030294.
[1]
Lücke J, Böttcher M, Nawrocki M, Meins N, Schnell J, Heinrich F, et al. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level. Heliyon 2024;10:e24508. https://doi.org/10.1016/j.heliyon.2024.e24508.
2023
[1]
Schädler J, Lütgehetmann M, Schröder AS, Edler C, Püschel K, Ondruschka B, et al. Pilot study in Hamburg on the prevalence of SARS-CoV-2 infections and pandemic survey in the German funeral industry. Forensic Sci Med Pathol 2024;20:500–7. https://doi.org/10.1007/s12024-023-00661-y.
[1]
Lutter M, Kniep I, Ondruschka B, Heinemann A. Pulmonale Befunde in der postmortalen Computertomographie bei COVID-19-assoziierten Todesfällen. Rechtsmedizin 2023;34:17–23. https://doi.org/10.1007/s00194-023-00667-4.
[1]
Schweizer L, Schaller T, Zwiebel M, Karayel Ö, Müller‐Reif JB, Zeng W, et al. Quantitative multiorgan proteomics of fatal COVID‐19 uncovers tissue‐specific effects beyond inflammation. EMBO Mol Med 2023;15:e17459. https://doi.org/10.15252/emmm.202317459.
[1]
Lopes S, Sousa AB de, Delalibera M, Namukwaya E, Cohen J, Gomes B. The rise of home death in the COVID-19 pandemic: a population-based study of death certificate data for adults from 32 countries, 2012–2021. EClinicalMedicine 2024;0. https://doi.org/10.1016/j.eclinm.2023.102399.
[1]
Mothes R, Pascual-Reguant A, Koehler R, Liebeskind J, Liebheit A, Bauherr S, et al. Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19. Nat Commun 2023;14:791. https://doi.org/10.1038/s41467-023-36333-2.
[1]
Schädler J, Azeke AT, Ondruschka B, Steurer S, Lütgehetmann M, Fitzek A, et al. Concordance between MITS and conventional autopsies for pathological and virological diagnoses. Int J Legal Med 2023. https://doi.org/10.1007/s00414-023-03088-w.
[1]
Azeke AT, Schädler J, Ondruschka B, Steurer S, Möbius D, Fitzek A. Minimally Invasive Tissue Sampling via Post Mortem Ultrasound: A Feasible Tool (Not Only) in Infectious Diseases-A Case Report. Diagnostics (Basel) 2023;13:2643. https://doi.org/10.3390/diagnostics13162643.
[1]
Heinrich F, Mertz KD, Glatzel M, Beer M, Krasemann S. Using autopsies to dissect COVID-19 pathogenesis. Nat Microbiol 2023:1–9. https://doi.org/10.1038/s41564-023-01488-7.
[1]
Woo MS, Shafiq M, Fitzek A, Dottermusch M, Altmeppen H, Mohammadi B, et al. Vagus nerve inflammation contributes to dysautonomia in COVID-19. Acta Neuropathol 2023;146:387–94. https://doi.org/10.1007/s00401-023-02612-x.
[1]
Stanelle-Bertram S, Beck S, Mounogou NK, Schaumburg B, Stoll F, Al Jawazneh A, et al. CYP19A1 mediates severe SARS-CoV-2 disease outcome in males. Cell Reports Medicine 2023:101152. https://doi.org/10.1016/j.xcrm.2023.101152.
[1]
Lücke J, Heinrich F, Malsy J, Meins N, Schnell J, Böttcher M, et al. Intestinal IL-1β Plays a Role in Protecting against SARS-CoV-2 Infection. The Journal of Immunology 2023:ji2200844. https://doi.org/10.4049/jimmunol.2200844.
[1]
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, et al. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell 2023:S0092867423007420. https://doi.org/10.1016/j.cell.2023.07.009.
[1]
Mieling R, Neidhardt M, Latus S, Stapper C, Gerlach S, Kniep I, et al. Collaborative Robotic Biopsy with Trajectory Guidance and Needle Tip Force Feedback. 2023 IEEE International Conference on Robotics and Automation (ICRA), 2023, p. 6893–900. https://doi.org/10.1109/ICRA48891.2023.10161377.
[1]
Aschman T, Wyler E, Baum O, Hentschel A, Legler F, Preusse C, et al. Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles 2023. https://doi.org/10.1101/2023.02.15.23285584.
[1]
Gagiannis D, Hackenbroch C, Bloch W, Zech F, Kirchhoff F, Djudjaj S, et al. Clinical, Imaging, and Histopathological Features of Pulmonary Sequelae Following Mild COVID-19. Am J Respir Crit Care Med 2023. https://doi.org/10.1164/rccm.202302-0285LE.
[1]
Bräutigam K, Reinhard S, Wartenberg M, Forster S, Greif K, Granai M, et al. Comprehensive analysis of SARS-CoV-2 receptor proteins in human respiratory tissues identifies alveolar macrophages as potential virus entry site. Histopathology 2023;82:846–59. https://doi.org/10.1111/his.14871.
[1]
Granai M, Warm V, Vogelsberg A, Milla J, Greif K, Vogel U, et al. Impact of P-selectin-PSGL-1 Axis on Platelet-Endothelium-Leucocyte Interactions in Fatal COVID-19. Lab Invest 2023:100179. https://doi.org/10.1016/j.labinv.2023.100179.
[1]
Heinrich F, Huter T, Mertens S, Lange P, Vering J, Heinemann A, et al. New Postmortem Perspective on Emerging SARS-CoV-2 Variants of Concern, Germany. Emerg Infect Dis 2023;29:652–6. https://doi.org/10.3201/eid2903.221297.
[1]
Lücke J, Nawrocki M, Schnell J, Meins N, Heinrich F, Zhang T, et al. TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver. Front Immunol 2023;14:1151937. https://doi.org/10.3389/fimmu.2023.1151937.
2022
[1]
Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, et al. Inflammation and vascular remodeling in COVID-19 hearts. Angiogenesis 2023;26:233–48. https://doi.org/10.1007/s10456-022-09860-7.
[1]
Gaede K, Heidemann J, Goebels H-L, Heinemann A, Püschel K, Ondruschka B. Pandemic Preparedness bei der Obduktion? Potentiale und Grenzen des IfSG. MedR 2022;40:892–901. https://doi.org/10.1007/s00350-022-6331-6.
[1]
Paparoupa M, Schröder AS, Braunsteiner J, Addo MM, Lütgehetmann M, Roedl K, et al. The Effects of SARS-CoV-2 Virus Type and of Vaccination Status on Causes of Death Over the Course of the COVID-19 Pandemic. Dtsch Arztebl Int 2022:607–8.
[1]
Ackermann M, Jonigk DD. Microvascular placental alterations in maternal COVID-19. Am J Obstet Gynecol 2022;226:135–6. https://doi.org/10.1016/j.ajog.2021.06.098.
[1]
Ackermann M, Tafforeau P, Wagner WL, Walsh CL, Werlein C, Kühnel MP, et al. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med 2022;205:121–5. https://doi.org/10.1164/rccm.202103-0594IM.
[1]
Ameratunga R, Woon S-T, Sheppard MN, Garland J, Ondruschka B, Wong CX, et al. First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction. J Clin Immunol 2022;42:441–7. https://doi.org/10.1007/s10875-021-01187-0.
[1]
Aschman T, Mothes R, Heppner FL, Radbruch H. What SARS-CoV-2 does to our brains. Immunity 2022;55:1159–72. https://doi.org/10.1016/j.immuni.2022.06.013.
[1]
Brandner JM, Boor P, Borcherding L, Edler C, Gerber S, Heinemann A, et al. Contamination of personal protective equipment during COVID-19 autopsies. Virchows Arch 2022;480:519–28. https://doi.org/10.1007/s00428-021-03263-7.
[1]
Bräuninger H, Stoffers B, Fitzek ADE, Meißner K, Aleshcheva G, Schweizer M, et al. Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart. Cardiovasc Res 2022;118:542–55. https://doi.org/10.1093/cvr/cvab322.
[1]
Casagrande M, Fitzek A, Spitzer M, Püschel K, Glatzel M, Krasemann S, et al. Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19. Br J Ophthalmol 2022;106:1313–7. https://doi.org/10.1136/bjophthalmol-2020-318618.
[1]
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, et al. Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell 2022;185:493-512.e25. https://doi.org/10.1016/j.cell.2021.12.040.
[1]
Heinrich F, Roedl K, Jarczak D, Goebels H-L, Heinemann A, Schäfer U, et al. New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19-A Large Postmortem and Clinical Analysis. Viruses 2022;14:811. https://doi.org/10.3390/v14040811.
[1]
Gagiannis D, Umathum VG, Bloch W, Rother C, Stahl M, Witte HM, et al. Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2. American Journal of Clinical Pathology 2022;157:54–63. https://doi.org/10.1093/ajcp/aqab087.
[1]
Hirschbühl K, Schaller T, Märkl B, Claus R, Sipos E, Rentschler L, et al. High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study. Mod Pathol 2022;35:1013–21. https://doi.org/10.1038/s41379-022-01069-9.
[1]
Neidhardt M, Gerlach S, Mieling R, Laves M-H, Weiß T, Gromniak M, et al. Robotic Tissue Sampling for Safe Post-Mortem Biopsy in Infectious Corpses. IEEE Transactions on Medical Robotics and Bionics 2022;4:94–105. https://doi.org/10.1109/TMRB.2022.3146440.
[1]
Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, et al. Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant. Int J Legal Med 2022;136:193–202. https://doi.org/10.1007/s00414-021-02618-8.
[1]
Heinrich F, Schröder AS, Gerberding A-L, Gerling M, Langenwalder F, Lange P, et al. Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths. Emerg Infect Dis 2022;28:244–7. https://doi.org/10.3201/eid2801.211749.
[1]
Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, et al. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell 2022;29:217-231.e8. https://doi.org/10.1016/j.stem.2021.12.010.
[1]
Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, et al. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Arch 2022;481:139–59. https://doi.org/10.1007/s00428-022-03319-2.
[1]
Kamp JC, Neubert L, Ackermann M, Stark H, Werlein C, Fuge J, et al. Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19. Int J Mol Sci 2022;23:1583. https://doi.org/10.3390/ijms23031583.
[1]
Krasemann S, Dittmayer C, von Stillfried S, Meinhardt J, Heinrich F, Hartmann K, et al. Assessing and improving the validity of COVID-19 autopsy studies – A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses. EBioMedicine 2022;83:104193. https://doi.org/10.1016/j.ebiom.2022.104193.
[1]
Pomara C, Salerno M, Miani A, Piscitelli P. Autopsies in COVID-related deaths: The need for following the model of German COVID-19 autopsy registry. Lancet Reg Health Eur 2022;17:100392. https://doi.org/10.1016/j.lanepe.2022.100392.
[1]
von Stillfried S, Bülow RD, Röhrig R, Boor P, German Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators. First report from the German COVID-19 autopsy registry. Lancet Reg Health Eur 2022;15:100330. https://doi.org/10.1016/j.lanepe.2022.100330.
[1]
von Stillfried S, Bülow RD, Röhrig R, Meybohm P, Boor P, German Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators#. Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report. Crit Care 2022;26:83. https://doi.org/10.1186/s13054-022-03945-x.
[1]
von Stillfried S, Freeborn B, Windeck S, Boor P. Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin. Pathologie (Heidelb) 2022;43:101–5. https://doi.org/10.1007/s00292-022-01117-w.
[1]
Voigtlaender M, Edler C, Gerling M, Schädler J, Ondruschka B, Schröder AS, et al. Thromboembolic events in deceased patients with proven SARS-CoV-2 infection: Frequency, characteristics and risk factors. Thromb Res 2022;218:171–6. https://doi.org/10.1016/j.thromres.2022.08.021.
[1]
Zickler M, Stanelle-Bertram S, Ehret S, Heinrich F, Lange P, Schaumburg B, et al. Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans. Cell Metab 2022;34:1–2. https://doi.org/10.1016/j.cmet.2021.12.002.
[1]
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, et al. Molecular consequences of SARS-CoV-2 liver tropism. Nat Metab 2022;4:310–9. https://doi.org/10.1038/s42255-022-00552-6.
2021
[1]
Reichardt M, Moller Jensen P, Andersen Dahl V, Bjorholm Dahl A, Ackermann M, Shah H, et al. 3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography. ELife 2021;10:e71359. https://doi.org/10.7554/eLife.71359.
[1]
Heinrich F, Meißner K, Langenwalder F, Püschel K, Nörz D, Hoffmann A, et al. Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa – Volume 27, Number 1—January 2021 – Emerging Infectious Diseases journal – CDC 2021. https://doi.org/10.3201/eid2701.203112.
[1]
Zack F, Nigbur S, Derani H, Boy D, Port A, Büttner A. Erste Ergebnisse der Obduktionen der im Zusammenhang mit den SARS-CoV-2-Infektionen Verstorbenen aus der Unimedizin Rostock. Ärztebl Meckl-Vorpom 2021;31:125–8.
[1]
Verhoff M, Püschel K, Ondruschka B. SARS-CoV-2: Was bei der Leichenschau infizierter Verstorbener zu beachten ist. MMW Fortschr Med 2021:56–8.
[1]
Püschel K, Goebels H, Ondruschka B, Heinrich F, Bräuninger H, Lindner D, et al. Kardiopathologische Befunde bei COVID-19-Sterbefällen 2021.
[1]
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, et al. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell 2021;184:6243-6261.e27. https://doi.org/10.1016/j.cell.2021.11.033.
[1]
Walsh CL, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, et al. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography. Nat Methods 2021;18:1532–41. https://doi.org/10.1038/s41592-021-01317-x.
[1]
van Rüth V, König H-H, Bertram F, Schmiedel P, Ondruschka B, Püschel K, et al. Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic. Public Health 2021;194:60–6. https://doi.org/10.1016/j.puhe.2021.02.026.
[1]
Verhoff M, Püschel K, Ondruschka B. Über die Ansteckungsgefahr beim Umgang mit SARS-CoV-2-positiven Leichen. Bestattungskultur 2021:24–8.
[1]
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature 2021;600:295–301. https://doi.org/10.1038/s41586-021-04142-6.
[1]
von Stillfried S, Boor P, DeRegCOVID und DEFEAT PANDEMIcs. Entwicklung eines kooperativen Obduktionsnetzwerks aus Pathologie, Neuropathologie und Rechtsmedizin. Pathologe 2021;42:129–34. https://doi.org/10.1007/s00292-021-01004-w.
[1]
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, et al. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci 2021;24:1522–33. https://doi.org/10.1038/s41593-021-00926-1.
[1]
Heinrich F, Nentwich MF, Bibiza-Freiwald E, Nörz D, Roedl K, Christner M, et al. SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients. Open Forum Infectious Diseases 2021;8:ofab509. https://doi.org/10.1093/ofid/ofab509.
[1]
Ondruschka B, Püschel K, Lange P, Becker I, Rieger-Ndakorerwa G, Schröder AS. SARS-CoV-2-assoziierte Hamburger Sterbefälle in der zweiten Pandemiewelle – Vergleich der bekannt gewordenen Todesfälle in den Gesundheitsämtern und der Rechtsmedizin. Archiv für Kriminologie 2021;248:180–7.
[1]
Michel P, Savinsky G, Ondruschka B, Czinczoll I. Folgen einer Reanimation in Zeiten der Pandemie. Hamburger Ärzteblatt 2021;2021:28–30.
[1]
Nörz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, et al. Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7. Journal of Clinical Virology 2021;141:104894. https://doi.org/10.1016/j.jcv.2021.104894.
[1]
Simnica D, Schultheiß C, Mohme M, Paschold L, Willscher E, Fitzek A, et al. Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts. Clinical & Translational Immunology 2021;10:e1340. https://doi.org/10.1002/cti2.1340.
[1]
Berezowska S, Boor P, Jonigk D, Tischler V. Update Thoraxpathologie 2021 – Bericht der Arbeitsgemeinschaft. Pathologe 2021;42:199–202. https://doi.org/10.1007/s00292-021-00991-0.
[1]
Lehmann M, Allers K, Heldt C, Meinhardt J, Schmidt F, Rodriguez-Sillke Y, et al. Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells. Mucosal Immunology 2021;14:1381–92. https://doi.org/10.1038/s41385-021-00437-z.
[1]
Menger J, Apostolidou S, Edler C, Kniep I, Kobbe R, Singer D, et al. Fatal outcome of SARS-CoV-2 infection (B1.1.7) in a 4-year-old child. Int J Legal Med 2022;136:189–92. https://doi.org/10.1007/s00414-021-02687-9.
[1]
Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, et al. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity 2021;54:1594-1610.e11. https://doi.org/10.1016/j.immuni.2021.06.002.
[1]
Edler C, Klein A, Schröder AS, Sperhake J-P, Ondruschka B. Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®). Legal Medicine 2021;51:101895. https://doi.org/10.1016/j.legalmed.2021.101895.
[1]
Gerlach S, Neidhardt M, Weiß T, Laves M-H, Stapper C, Gromniak M, et al. Needle insertion planning for obstacle avoidance in robotic biopsy. Current Directions in Biomedical Engineering 2021;7:779–82. https://doi.org/10.1515/cdbme-2021-2199.
[1]
Elezkurtaj S, Greuel S, Ihlow J, Michaelis EG, Bischoff P, Kunze CA, et al. Causes of death and comorbidities in hospitalized patients with COVID-19. Sci Rep 2021;11:4263. https://doi.org/10.1038/s41598-021-82862-5.
[1]
O’Hare M, Amarnani D, Whitmore HAB, An M, Marino C, Ramos L, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. The American Journal of Pathology 2021;191:1193–208. https://doi.org/10.1016/j.ajpath.2021.04.006.
[1]
Gromniak M, Neidhardt M, Heinemann A, Püschel K, Schlaefer A. Needle placement accuracy in CT-guided robotic post mortem biopsy. Current Directions in Biomedical Engineering 2020;6. https://doi.org/10.1515/cdbme-2020-0031.
[1]
Aschman T, Schneider J, Greuel S, Meinhardt J, Streit S, Goebel H-H, et al. Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died. JAMA Neurology 2021;78:948–60. https://doi.org/10.1001/jamaneurol.2021.2004.
[1]
Kruse JM, Zickler D, Lüdemann WM, Piper SK, Gotthardt I, Ihlow J, et al. Evidence for a thromboembolic pathogenesis of lung cavitations in severely ill COVID-19 patients. Sci Rep 2021;11:16039. https://doi.org/10.1038/s41598-021-95694-0.
[1]
Dittmayer C, Meinhardt J, Radbruch H, Radke J, Heppner BI, Heppner FL, et al. Using EM data to understand COVID-19 pathophysiology – Authors’ reply. The Lancet 2021;397:197–8. https://doi.org/10.1016/S0140-6736(21)00032-5.
[1]
Ihlow J, Michaelis E, Greuel S, Heynol V, Lehmann A, Radbruch H, et al. B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased. International Journal of Infectious Diseases 2021;103:628–35. https://doi.org/10.1016/j.ijid.2020.12.078.
[1]
Greuel S, Ihlow J, Dragomir M-P, Streit S, Corman VM, Haberbosch L, et al. COVID-19: Autopsy findings in six patients between 26 and 46 years of age. International Journal of Infectious Diseases 2021;108:274–81. https://doi.org/10.1016/j.ijid.2021.05.069.
[1]
Ihlow J, Seelhoff A, Corman VM, Gruber AD, Dökel S, Meinhardt J, et al. COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis. BMC Infectious Diseases 2021;21:901. https://doi.org/10.1186/s12879-021-06605-7.
[1]
Fitzek A, Schädler J, Dietz E, Ron A, Gerling M, Kammal AL, et al. Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases. Sci Rep 2021;11:19342. https://doi.org/10.1038/s41598-021-98499-3.
[1]
Swoboda J, Wittschieber D, Sanft J, Kleemann S, Elschner S, Ihle H, et al. Bone marrow haemophagocytosis indicates severe infection with severe acute respiratory syndrome coronavirus 2. Histopathology 2021;78:727–37. https://doi.org/10.1111/his.14281.
[1]
Kaltschmidt B, Fitzek ADE, Schaedler J, Förster C, Kaltschmidt C, Hansen T, et al. Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19. Clinical Gastroenterology and Hepatology 2021;19:1726-1729.e3. https://doi.org/10.1016/j.cgh.2021.01.044.
[1]
Kahn M, Schuierer L, Bartenschlager C, Zellmer S, Frey R, Freitag M, et al. Performance of antigen testing for diagnosis of COVID-19: a direct comparison of a lateral flow device to nucleic acid amplification based tests. BMC Infectious Diseases 2021;21:798. https://doi.org/10.1186/s12879-021-06524-7.
[1]
Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, et al. COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis 2021;24:755–88. https://doi.org/10.1007/s10456-021-09805-6.
[1]
Rank A, Tzortzini A, Kling E, Schmid C, Claus R, Löll E, et al. One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms. Journal of Clinical Medicine 2021;10:3305. https://doi.org/10.3390/jcm10153305.
[1]
Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchón FJ, et al. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLOS ONE 2021;16:e0255335. https://doi.org/10.1371/journal.pone.0255335.
[1]
Hansen T, Titze U, Kulamadayil-Heidenreich NSA, Glombitza S, Tebbe JJ, Röcken C, et al. First case of postmortem study in a patient vaccinated against SARS-CoV-2. International Journal of Infectious Diseases 2021;107:172–5. https://doi.org/10.1016/j.ijid.2021.04.053.
[1]
Ondruschka B, Heinrich F, Lindenmeyer M, Edler C, Möbius D, Czogalla J, et al. Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7. Int J Legal Med 2021;135:2347–9. https://doi.org/10.1007/s00414-021-02691-z.
[1]
Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM, et al. Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients. Cells 2021;10:1900. https://doi.org/10.3390/cells10081900.
[1]
Guarino M, Cossiga V, Esposito I, Furno A, Morisco F. Effectiveness of SARS-CoV-2 vaccination in liver transplanted patients: The debate is open! Journal of Hepatology 2022;76:237–9. https://doi.org/10.1016/j.jhep.2021.07.034.
[1]
von Stillfried S, Villwock S, Bülow RD, Djudjaj S, Buhl EM, Maurer A, et al. SARS-CoV-2 RNA screening in routine pathology specimens. Microbial Biotechnology 2021;14:1627–41. https://doi.org/10.1111/1751-7915.13828.
[1]
Nörz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, Lütgehetmann M. Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay. The Journal of Molecular Diagnostics 2021;23:777–8. https://doi.org/10.1016/j.jmoldx.2021.03.007.
[1]
Tampe D, Hakroush S, Bösherz M-S, Franz J, Hofmann-Winkler H, Pöhlmann S, et al. Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. Frontiers in Medicine 2021;8.
[1]
Schröder AS, Edler C, Ondruschka B, Püschel K, Schädler J, Heinemann A, et al. The handling of SARS-CoV-2 associated deaths - infectivity of the body. Forensic Sci Med Pathol 2021;17:411–8. https://doi.org/10.1007/s12024-021-00379-9.
[1]
Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, et al. Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica 2021;106:2170–9. https://doi.org/10.3324/haematol.2021.279000.
[1]
Bayyoud T, Iftner A, Iftner T, Bartz-Schmidt KU, Ziemssen F, Bösmüller H, et al. Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina? PLOS ONE 2021;16:e0251682. https://doi.org/10.1371/journal.pone.0251682.
[1]
Klein A, Langenwalder F, Heinrich F, Meißner K, Schröder AS, Püschel K, et al. SARS-CoV‑2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020. Rechtsmedizin 2021;31:427–33. https://doi.org/10.1007/s00194-021-00481-w.
2020
[1]
Subbarayan K, Ulagappan K, Wickenhauser C, Seliger B. Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues. Current Cancer Drug Targets 2020;21:428–42.
[1]
Püschel K, Frenkel A, Mull G, Birkholz H, Hengfoss C. COVID-19-Prävention: Einsatz von Fieberkameras zum Schutz vor COVID-19. der kriminalist 2020;11–2020.
[1]
Kommoss FKF, Schwab C, Tavernar L, Schreck J, Wagner WL, Merle U, et al. The Pathology of Severe COVID-19-Related Lung Damage. Dtsch Arztebl Int 2020;117:500–6. https://doi.org/10.3238/arztebl.2020.0500.
[1]
Lauermann P, Storch M, Weig M, Tampe B, Winkler M, Hoerauf H, et al. There is no intraocular affection on a SARS-CoV-2 – Infected ocular surface. American Journal of Ophthalmology Case Reports 2020;20:100884. https://doi.org/10.1016/j.ajoc.2020.100884.
[1]
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 2020;370:856–60. https://doi.org/10.1126/science.abd2985.
[1]
Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, et al. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovascular Research 2020;116:2207–15. https://doi.org/10.1093/cvr/cvaa267.
[1]
Boor P, Hartmann A. Bericht zur Late-Breaking Session Pathologie und COVID-19. Pathologe 2020;41:96–8. https://doi.org/10.1007/s00292-020-00882-w.
[1]
Hüppe D, Niederau C, Serfert Y, Hartmann H, Wedemeyer H, Dhc-R FD. Versorgungsprobleme von Patienten mit chronischer Hepatitis C während der COVID-19-Pandemie und der Lockdown-Verordnungen. Z Gastroenterol 2020;58:1182–5. https://doi.org/10.1055/a-1291-8518.
[1]
Matschke J, Lütgehetmann M, Hagel C, Sperhake JP, Schröder AS, Edler C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. The Lancet Neurology 2020;19:919–29. https://doi.org/10.1016/S1474-4422(20)30308-2.
[1]
Lang P, Eichholz T, Bakchoul T, Streiter M, Petrasch M, Bösmüller H, et al. Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients. Journal of the Pediatric Infectious Diseases Society 2020;9:622–5. https://doi.org/10.1093/jpids/piaa117.
[1]
Lindner D, Fitzek A, Bräuninger H, Aleshcheva G, Edler C, Meissner K, et al. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiology 2020;5:1281–5. https://doi.org/10.1001/jamacardio.2020.3551.
[1]
Bojkova D, Bechtel M, McLaughlin K-M, McGreig JE, Klann K, Bellinghausen C, et al. Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020;9:2377. https://doi.org/10.3390/cells9112377.
[1]
Trigaux C, Salla S, Schroeter J, Tourtas T, Thomasen H, Maier P, et al. SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks. Current Eye Research 2021;46:666–71. https://doi.org/10.1080/02713683.2020.1828487.
[1]
Gagiannis D, Steinestel J, Hackenbroch C, Schreiner B, Hannemann M, Bloch W, et al. Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD). Frontiers in Immunology 2020;11.
[1]
Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med 2020;383:120–8. https://doi.org/10.1056/NEJMoa2015432.
[1]
Sperhake J-P. Autopsies of COVID-19 deceased? Absolutely! Legal Medicine 2020;47:101769. https://doi.org/10.1016/j.legalmed.2020.101769.
[1]
Schrappe M, Francois-Kettner H, Knieps F, Pfaff H, Püschel K, Glaeske G. Die Pandemie durch SARS-CoV-2/Covid-19 – der Übergang zur chronischen Phase. Monitor Versorgungsforschung 2020;5:35–68.
[1]
Kniep I, Lutter M, Ron A, Edler C, Püschel K, Ittrich H, et al. Postmortale Bildgebung der Lunge bei COVID-19-Todesfällen. Radiologe 2020;60:927–33. https://doi.org/10.1007/s00117-020-00733-y.
[1]
Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy. Circulation 2020;142:1176–89. https://doi.org/10.1161/CIRCULATIONAHA.120.048488.
[1]
Goebels H, Edler C, Fitzek A, Schädler J, Schröder AS, Kniep I, et al. Obduktionen bei COVID-19. Pathologische Veränderungen und Organmanifestationen. Der Klinikarzt 2020;49:404–8. https://doi.org/10.1055/a-1260-9966.
[1]
Wiech T, Sperhake J-P, Zipfel PF, Huber TB. Nierenpathologische Befunde bei COVID-19-Patienten. Der Klinikarzt 2020;49:425–8. https://doi.org/10.1055/a-1262-0048.
[1]
Wagner WL, Hellbach K, Fiedler MO, Salg GA, Wehrse E, Ziener CH, et al. Mikrovaskuläre Veränderungen bei COVID-19. Radiologe 2020;60:934–42. https://doi.org/10.1007/s00117-020-00743-w.
[1]
Bösmüller H, Traxler S, Bitzer M, Häberle H, Raiser W, Nann D, et al. The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. Virchows Arch 2020;477:349–57. https://doi.org/10.1007/s00428-020-02881-x.
[1]
Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, et al. 3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography. ELife 2020;9:e60408. https://doi.org/10.7554/eLife.60408.
[1]
Heinrich F, Sperhake J-P, Heinemann A, Mushumba H, Lennartz M, Nörz D, et al. Germany’s first COVID-19 deceased: a 59-year-old man presenting with diffuse alveolar damage due to SARS-CoV-2 infection. Virchows Arch 2020;477:335–9. https://doi.org/10.1007/s00428-020-02872-y.
[1]
Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, et al. SARS-CoV-2 renal tropism associates with acute kidney injury. The Lancet 2020;396:597–8. https://doi.org/10.1016/S0140-6736(20)31759-1.
[1]
Fuest M, Boor P, Knuechel R, DeRegCOVID FT, Walter P, Salla S. Postmortem conjunctival and nasopharyngeal swabs in SARS-CoV-2 infected and uninfected patients. Acta Ophthalmologica 2021;99:e615–7. https://doi.org/10.1111/aos.14559.
[1]
von Stillfried S, Bülow RD, Röhrig R, Knüchel-Clarke R, Boor P, the D. Autopsy registry can facilitate COVID-19 research. EMBO Molecular Medicine 2020;12:e12885. https://doi.org/10.15252/emmm.202012885.
[1]
Wichmann D, Sperhake J-P, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19. Ann Intern Med 2020;173:268–77. https://doi.org/10.7326/M20-2003.
[1]
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, et al. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med 2020;383:590–2. https://doi.org/10.1056/NEJMc2011400.
[1]
Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, et al. Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine 2020;58:102925. https://doi.org/10.1016/j.ebiom.2020.102925.
[1]
Casagrande M, Fitzek A, Püschel K, Aleshcheva G, Schultheiss H-P, Berneking L, et al. Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients. Ocular Immunology and Inflammation 2020;28:721–5. https://doi.org/10.1080/09273948.2020.1770301.
[1]
Edler C, Schröder AS, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, et al. Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany. Int J Legal Med 2020;134:1275–84. https://doi.org/10.1007/s00414-020-02317-w.
[1]
Schreck J, Baretton G, Schirmacher P. Situation der Deutschen Universitätspathologien unter den Einschränkungen der Corona-Pandemie – Auswertung einer ersten repräsentativen Umfrage. Pathologe 2020;41:400–5. https://doi.org/10.1007/s00292-020-00791-y.
[1]
Klein A, Edler C, Fitzek A, Fröb D, Heinemann A, Meißner K, et al. Der erste COVID-19-Hotspot in einer Hamburger Senioreneinrichtung: Präventionskonzept, Letalität und Obduktionsbefunde. RECHTSMEDIZIN 2020;30:325–31. https://doi.org/10.1007/s00194-020-00404-1.
[1]
Püschel K, Sperhake JP. Corona deaths in Hamburg, Germany. Int J Legal Med 2020;134:1267–9. https://doi.org/10.1007/s00414-020-02332-x.
[1]
Püschel K, Kluge S, Addo MM, Aepfelbacher M. Von den Toten lernen – neue Erkenntnisse zu Covid-19. Hamburger Ärzteblatt 2020;73:34–6.
[1]
Fitzek A, Sperhake J, Edler C, Schröder AS, Heinemann A, Heinrich F, et al. Evidence for systematic autopsies in COVID-19 positive deceased. Rechtsmedizin 2020;30:184–9. https://doi.org/10.1007/s00194-020-00401-4.
[1]
Schädler J, Gerling M, Edler C. Covid-19-Pneumonie und rezidivierende Lungenembolien. Hamburger Ärzteblatt 2020:36–7.
[1]
Ramsthaler F, Heinbuch S, Schmidt PH, Bohle RM, Rissland J, Gärtner B, et al. Aktuelle Empfehlungen zum Umgang mit dem Verdacht auf COVID-19 in der rechtsmedizinischen Routine. Archiv Für Kriminologie 2020;245.
[1]
Ron A, Püschel K. Todesursachen im Zusammenhang mit Infektionen durch SARS-CoV-2. WUNDmanagement 2020.